Recent Selected Publications (2002-2008)

Zhang C, Li WH, Krainer AR, Zhang MQ. (2008) RNA landscape of evolution for optimal exon and intron discrimination. Proc Natl Acad Sci U S A.105(15):5797-802.

Chen CY, Tsai HK, Hsu CM, May Chen MJ, Hung HG, Huang GT, Li WH.(2008) Discovering gapped binding sites of yeast transcription factors. Proc Natl Acad Sci U S A. 105(7):2527-32.

Liang H, Plazonic RK, Chen J, Li WH, Fernández A. (2008) Protein under-wrapping causes dosage sensitivity and decreases gene duplicability. PLoS Genet. 4(1): e11

Prachumwat A, Li WH. (2008) Gene number expansion and contraction in vertebrate genomes with respect to invertebrate genomes. Genome Res.18(2): 221-232

Liang H, Li WH. (2007) Gene essentiality, gene duplicability and protein connectivity in human and mouse. Trends Genet. 23(8):375-378

Hanada K, Zhang X, Borevitz JO, Li WH, Shiu SH. (2007) A large number of novel coding small open reading frames in the intergenic regions of the Arabidopsis thaliana genome are transcribed and/or under purifying selection. Genome Res. 17(5):632-640.

Saunders MA*, Liang H*, Li WH.(2007) Human polymorphism at microRNAs and microRNA target sites. Proc Natl Acad Sci U S A. 104(9):3300-5. [* equally contributed]

Saunders MA, Good JM, Lawrence EC, Ferrell RE, Li WH, Nachman MW. (2006) Human adaptive evolution at Myostatin (GDF8), a regulator of muscle growth. Am J Hum Genet. 79(6):1089-1097.

Lin YS, Byrnes JK, Hwang JK, Li WH. (2006) Codon-usage bias versus gene conversion in the evolution of yeast duplicate genes. Proc Natl Acad Sci U S A.103(39):14412-14416.

Shiu SH, Byrnes JK, Pan R, Zhang P, Li WH. (2006) Role of positive selection in the retention of duplicate genes in mammalian genomes. Proc Natl Acad Sci U S A. 103(7):2232-2236.

Tan Y, Yoder AD, Yamashita N, Li WH. (2005) Evidence from opsin genes rejects nocturnality in ancestral primates. Proc Natl Acad Sci U S A. 102(41):14712-14716.

Li WH, Yang J, Gu X. (2005) Expression divergence between duplicate genes. Trends Genet. 21(11):602-607.

Li WH, Saunders MA. (2005) News and views: the chimpanzee and us. Nature 437(7055):50-51.

Gu Z, Rifkin SA, White KP, Li WH. (2004) Duplicate genes increase gene expression diversity within and between species. Nat Genet. 36(6):577-579.

Yi S, Summers TJ, Pearson NM, Li WH.(2004) Recombination has little effect on the rate of sequence divergence in pseudoautosomal boundary 1 among humans and great apes. Genome Res.14(1):37-43.

Yang J, Lusk R, Li WH. Organismal complexity, protein complexity, and gene duplicability. (2003) Proc Natl Acad Sci U S A. 100(26):15661-15665.

Lu J, Li WH, Wu CI. (2003) Comment on "Chromosomal speciation and molecular divergence-accelerated evolution in rearranged chromosomes". Science302(5647):988.

Qin H, Lu HH, Wu WB, Li WH. (2003) Evolution of the yeast protein interaction network. Proc Natl Acad Sci U S A. 100(22):12820-12824.

Makova KD, Li WH. (2003) Divergence in the spatial pattern of gene expression between human duplicate genes. Genome Res. 13(7):1638-1645.

Nekrutenko A, Chung WY, Li WH. (2003) An evolutionary approach reveals a high protein-coding capacity of the human genome. Trends Genet. 19(6):306-10.

Wolfe KH, Li WH. (2003) Molecular evolution meets the genomics revolution. Nat Genet. 33 Suppl:255-65.

Gu Z, Steinmetz LM, Gu X, Scharfe C, Davis RW, and Li WH. (2003) Role of duplicate genes in genetic robustness against null mutations. Nature 421:63-66.

Gu Z, Nicolae D, Lu HH, Li WH. (2002) Rapid divergence in expression between duplicate genes inferred from microarray data. Trends Genet. 18(12):609-613.

Kaessmann H, Zollner S, Nekrutenko A, Li WH. (2002) Signatures of domain shuffling in the human genome. Genome Res.12(11):1642-50.

Mu J, Duan J, Makova KD, Joy DA, Huynh CQ, Branch OH, Li WH, Su XZ. (2003) Chromosome-wide SNPs reveal an ancient origin for Plasmodium falciparum. Nature 418(6895):323-326.

Makova KD, Li WH. (2002) Strong male-driven evolution of DNA sequences in humans and apes. Nature 416(6881):624-6.