Disclaimer:  The following information is drawn from materials prepared by candidates for promotion to associate professor in one of the scholarship-requiring tracks (RS and CS).  It is intended to illustrate activities and materials that might support promotion.  In using these materials, please note the following:

               *The Provost (and, in some cases, the President) are the University officers authorized to approve promotions.  All levels of review below these officers are advisory.

               *Only Departments are empowered to propose promotions, and the Divisional Dean is charged with transmitting such proposals to the Provost or returning them to the Department.

               *The judgment of the Department, Dean, and Provost will therefore be critical to assessing qualification for promotion.

               *Materials considered by the Department, Dean, and Provost will also (and always) include confidential evaluations obtained from outside the University.  Materials considered by the Provost will include the confidential evaluations of the Dean and Department, and those considered by the Dean will include the confidential evaluations of the Department.

               *Thus, the following materials are ONLY PART of a complete proposal for promotion, whereas promotion is based on the ENTIRE proposal.   Therefore, it should not be assumed that a record comparable to that below will necessarily result in promotion, or that a record not comparable to that below will fail to result in promotion.  The Departmental Chair is likely to be the best source of advice as to whether promotion is feasible and, when it is not, what additional activity may result in qualification for promotion.

               *This document has been prepared as a tool for use by assistant professors in the Division of the Biological Sciences.  Other individuals who may find it informative are Department Chairmen, Section Heads, Committee Chairmen, senior faculty and potential recruits.  Its intent is to help guide individuals and their departments as they think about promotion to Professor.  This document is not intended to list the elements that every promotion proposal will be expected to address.  The following information is presented for information purposes only and is not intended to create any contract or agreement, and its contents are subject to addition, deletion, and change without prior notice.

Name:

Anning Lin

 

Primary Appointment:

Ben May Institute for Cancer Research

 

Secondary appointments:

Committee on Cancer Biology

 

Proposed rank:

PROFESSOR

 

Field or specialization within the life sciences and medicine?

Signal transduction

LAY SUMMARY:

Dr. Lin’s work has addressed a fundamental question in cell biology:  what determines whether cells survive or die?  The signals within the cell that determine the outcome are a complex interplay that resemble an electrical circuit.  Dr. Lin has illustrated the complexity of these signaling pathways and demonstrated that the answer is completely context dependent and can differ between cells and in response to different signals.  Thus, early on Dr. Lin showed that inhibition of the JNK signaling pathway by the putative survival factor NFkB enables cell survival in response to Tumor Necrosis factor.  More recently he showed that the same “survival” factor NFkB  activates JNK in response to UV light but now causes cell death.  Thus, the action of even well-characterized survival factors can lead to cell death dependent on the cellular context.  Dr. Lin  has also shown that JNK does not always cause cell death but instead can prevent death in hematopoietic cells in response to IL-3.  These concepts are quite novel and will lead to rich new avenues of investigation.  Dr. Lin has also looked at the interplay of various signaling pathways in response to other stress or growth stimuli.  Overall, his most significant contribution is in understanding the interplay or “crosstalk” between these different signaling pathways; the outcome of this interplay determines critical decisions by cells as to whether they grow, differentiate or die.   Dr. Lin has also been an effective teacher of cellular signaling both to graduate students and medical students within the Division of Biological Sciences.

Curriculum vitae

PROFESSIONAL SOCIETIES:

 

American Association for the Advancement of Science

American Society for Microbiology

 

JOURNAL/STUDY-SECTION REFEREE:

 

Cell

Molecular Cell

Nature Cell Biology

Genes & Development

EMBO Journal

Proceedings of the National Academy of Science USA

Molecular and Cellular Biology

EMBO Report

Journal of Biological Chemistry

Journal of Cell Biology

Cancer Research

Journal of Clinic Investigation

Oncogene

American Journal of Physiology

Molecular Pharmacology

Cell Growth and Differentiation

FESEB Journal

 

NIH Study Section (CSD, formally CDF3)

Chinese National Science Foundation

UICC (International Union Against Cancer)

Italian Association for Cancer Research (AIRC)

Israeli Science Foundation

US-Israel Binational Science Foundation

Cancer Research UK                                    

 

PROFESSIONAL ACTIVITIES

 

Organization of Meetings:

 

2001- present                            Member of the organization committee, Chicago Signal Transduction Symposium    

2001                                                                     Mini-symposium Co-Chair, AACR Annual meeting

2002                                              Member of the organization committee, Cancer Biology Program Retreat

2002                                              Section Chair, Ben May Symposium on Cell death, Cell Cycle and Cancer

2004                                    Organizer of Shanghai Symposium: the First International

                                            Symposium on Signal Transduction and Cancer, Shanghai, China,                             August 29-Septermber 1, 2004.  *  The meeting has a first-class line-up                     of invited speakers in the field: 

                                 http://ben-may.bsd.uchicago.edu/bmi/symposium/shangHai/Lin/home.htm

                                                                          

PRESENTATIONS:

Since last FIVE years

 

1999               Seminar, University of California, Las Angeles: “Activating transcription c-Jun                            and NF-kB: The JNK and IKK signaling pathways”.                          

1999                Seminar, Ben May Institute for Cancer Research, University of Chicago: “Activating transcription c-Jun and NF-kB: The JNK and IKK signaling pathways”.

2000                   Seminar, Committee on Cancer Biology retreat, University of Chicago: “Activating transcription c-Jun and NF-kB: The JNK and IKK signaling pathways”.

 2000                  Invited Speaker, Chinese Society for Biochemistry Annual Meeting: “Activating transcription c-Jun and NF-kB: The JNK and IKK signaling pathways”.

2000                Seminar, University of Illinois at Chicago: “Activating transcription c-Jun and NF-kB: The JNK and IKK signaling pathways”.

1999                             Seminar, Chicago Prostate Cancer Interacting Group: “Activating transcription c-Jun and NF-kB: The JNK and IKK signaling pathways”.

Mar. 25, 2001               Invited speaker and co-chair, Mini-symposium “Defining Genes and Mechanisms Regulating Metastasis”, American Association for Cancer Research 92 annual meeting, New Orleans, LA, March 24-28, 2001: “Identification of IKKb as a potential prostate metastasis suppressor”.    

May 31, 2001 Section Chair, the First Annual Student Workshop in Prostate Cancer Metastasis, University of Chicago.                                                               

Nov. 20, 2001               Visiting Lecturer of the Distinguished Lecture Series, Department of Cancer Biology, Lerner Cancer Research Institute, Cleveland Clinic Foundation: “Integration of TNF-a Signaling: Crosstalk between JNK, IKK and Caspases”.

Jan. 15, 2002  Seminar, University of North Carolina, Chapel Hill, NC: “Integration of TNF-a  Signaling: Crosstalk between JNK, IKK and Caspases”.

Jan. 16, 2002  Seminar, National Cancer Institute, NIH: “Integration of TNF-a Signaling: Crosstalk between JNK, IKK and Caspases”.

Jan. 23, 2002  Seminar, Ben May Institute for Cancer Research, University of Chicago: “Integration of TNF-a Signaling: Crosstalk between JNK, IKK and Caspases”.

Feb. 5, 2002    Seminar, Shanghai Institutes for Biological Sciences, Chinese Academy of Sciences, Shanghai, China: “Integration of TNF-a  Signaling: Crosstalk between JNK, IKK and Caspases”.

Feb. 20, 2002 Seminar, Rutgers University, NJ: “Integration of TNF-a Signaling: Crosstalk between JNK, IKK and Caspases”.

Mar. 1, 2002   Invited Speaker, Keystone Symposium “NF-kB: Bench to Bedside”, Keystone, CO: “Integration of TNF-a Signaling: Crosstalk between JNK and IKK”.

April 8, 2002  Seminar, Columbia University, NY: “Integration of TNF-a Signaling: Crosstalk between JNK, IKK and Caspases”.

April 22, 2002              Seminar, University of Texas, Houston Health Science Center, TX: “Integration of TNF-a Signaling: Crosstalk between JNK, IKK and Caspases”.

April 29, 2002 Seminar, National Institute for Occupational Safety and Health, NIH: “Integration of TNF-a Signaling: Crosstalk between JNK, IKK and Caspases”.

May 3, 2002   Seminar, Cancer Center, University of Chicago: “The possible role of the IKK/NF-kB signaling pathway in prostate cancer”.

Sept. 2, 2002  Invited Speaker, The Second International Symposium on Programmed Cell Death, Shanghai, China, September 1-3, 2002.  “Integration of TNF-a Signaling: Crosstalk between JNK, IKK and Caspases”. 

                        *  The meeting has a first-class line-up of invited speakers in the field.  

Sept. 15, 2003               Seminar, Emory University: “Signal Integration in Apoptosis: Tales of IKK and JNK”.

March 8, 2004 Seminar, Loyola University: “Signal Integration in Apoptosis: Tales of IKK and JNK”.

May 3, 2004   Seminar, NIH: “Signal Integration in Apoptosis: Tales of IKK and JNK”.

July 21, 2004  Seminar, University of Chicago: “Signal transduction meets apoptosis: Tales of IkB kinase and c-Jun kinase”.

Aug. 30, 2004               Organizer and invited speaker, The First International Symposium on Signal Transduction and Cancer, Shanghai, China, August 29-Spetember 1, 2004. “Signal Integration in Apoptosis: Tales of IKK and JNK”. 

                        *  The meeting has a first-class line-up of invited speakers in the field.  

                        http://ben-may.bsd.uchicago.edu/bmi/symposium/shangHai/Lin/home.htm

Sept. 3, 2004  Seminar, Nanjing University, Nanjing, China: “The Role of JNK in Apoptosis: A Double-edged Sword’.

Oct.28, 2004   Seminar, Brown University, Rhode Island, “The Role of JNK in Apoptosis: A Double-edged Sword”.

April 14, 2005 Seminar, UCLA: “Regulation of Apoptosis by JNK: A Double-edged Sword”.

June 13, 2005  Invited speaker, “Regulation of programmed cell death and cell survival by IKK and JNK”.  The 3rd Cao Tian-qin Memorial Symposium on Protein Research, Hangzhou, China, June 13-16, 2005.

July 16, 2005 Invited speaker, “Regulation of Apoptosis by JNK: A Double-edged Sword". 2005 FASEB Summer Research Conference on "Protein Kinases and Protein Phosphorylation", July 16- 21, 2005 at Snowmass, Colorado. 

Jan.10, 2006   Seminar, Nanjing University, Nanjing, China: “Regulation of Apoptosis by JNK”

Jan. 13, 2006   Seminar, Institute of Biochemistry and Cell Biology, Chinese Academy of Sciences, Shanghai, China: “The JNK Pathway: Signaling, Regulation and Biological Functions”.

Jan. 16, 2006   Invited speaker, “Regulation of JNK by NF-kB: A Life or Death Decision”.  Croucher Advanced Study Institute on “Signaling in Cell Growth and Proliferation”, January 16-20, Hong Kong University of Science and Technology, HK, China.

Feb. 21, 2006  Seminar, Blood Research Institute, BloodCenter of Wisconsin, “The JNK Pathway: Signaling, Regulation and Biological Functions”.

April 14, 2006 Seminar, Rutgers University, NJ: “Signaling by JNK: Pathway, Regulation and Biological Functions”.