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Disclaimer: The following information is drawn from materials prepared
by candidates for promotion to full professor. It is intended to illustrate activities and materials that
might support promotion. In
using these materials, please note the following:
*The Provost (and, in some cases, the President) are the University
officers authorized to approve promotions. All levels of review below these officers are advisory.
*Only Departments
are empowered to propose promotions, and the Divisional Dean is charged with
transmitting such proposals to the Provost or returning them to the
Department. *The judgment of the Department, Dean, and
Provost will therefore be critical to assessing qualification for promotion.
*Materials considered by the Department, Dean, and Provost will also
(and always) include confidential evaluations obtained from outside the
University. Materials considered
by the Provost will include the confidential evaluations of the Dean and
Department, and those considered by the Dean will include the confidential
evaluations of the Department.
*Thus, the following materials are ONLY PART of a complete proposal
for promotion, whereas promotion is based on the ENTIRE proposal. Therefore, it should not be
assumed that a record comparable to that below will necessarily result in
promotion, or that a record not comparable to that below will fail to result
in promotion. The Departmental
Chair is likely to be the best source of advice as to whether promotion is
feasible and, when it is not, what additional activity may result in
qualification for promotion.
*This document has been prepared as a tool for use by associate professors
in the Division of the Biological Sciences. Other individuals who may find it informative are
Department Chairmen, Section Heads, Committee Chairmen, senior faculty and
potential recruits. Its intent
is to help guide individuals and their departments as they think about
promotion to Professor. This
document is not intended to list the elements that every promotion proposal
will be expected to address. The
following information is presented for information purposes only and is not
intended to create any contract or agreement, and its contents are subject to
addition, deletion, and change without prior notice. |
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Name
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Douglas K. Bishop, Ph.D. |
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Department of Primary Appointment: |
Radiation and Cellular Oncology |
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Secondary appointments: |
Department of Molecular Genetics and Cell Biology Committee on Genetics Committee on Cancer Biology |
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Proposed rank: |
PROFESSOR |
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Proposed track: |
RESEARCH SCHOLAR (TENURE) |
DEPARTMENT: What is the candidate's field or specialization ?
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Primary
interest: Meiotic Recombination Secondary
interest: Regulation of recombinational repair of DNA damage. |
LAY SUMMARY:
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Dr. Bishop made several discoveries. First, he discovered Dmc1,
one of two proteins that promote meiotic recombination in a wide range of
eukaryotes including yeast, mice, plants, and humans. Second, as an assistant
professor at U of C. he developed the first light microscopy method for
examining the assembly of multiprotein recombination complexes in cells.
Third, he used light microscopy to identify several proteins that control the
assembly of recombination complexes in meiotic and mitotic cells. Work on
assembly factors was extended from yeast to vertebrate cells. Fourth, as an associate professor Dr.
Bishop provided critical evidence that a mechanism of recombination known as
synthesis dependent strand annealing occurs during meiosis. Fifth, Dr. Bishop
provided important data supporting the hypothesis that the recombinase Dmc1
functions in a manner similar to that of its recombinase relatives, rather
than functioning by a novel mechanism as had been suggested by others. Sixth, Dr. Bishop showed that a key
accessory factor for recombination expends energy to disassemble
non-functional recombination complexes.
Seventh, Dr. Bishop showed that overexpression of recombinase can
suppress the DNA repair defects caused by loss of breast tumor suppressor
gene BRCA1. Dr. Bishop is
active in teaching, with more than 30 lecture hours per year. He is course
director for two graduate courses in genetics, including a course entitled
Genetic Analysis of Model Organisms taken by around 40 first-year graduate
students in several Ph.D. programs.
Dr. Bishop also has a long-term commitment to teach introductory
genetics in the college. Dr.
Bishop has served in a variety of administrative capacities in BSD and in the
larger Biology community. Most
notably, Dr. Bishop is chairman of the Committee on Genetics. He also served
as chairman of the Gordon Conference on Meiosis, indicating that he is an
international leader in this field.
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CURRICULUM VITAE
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Extramural Service 1993-1996 Leukemia
Research Foundation, Scientific Advisory Board, grant
review 1994-1997, 2003 National
Science Foundation, ad hoc grant review 1995-1996 United
States Department of Agriculture, ad hoc grant review 1998, 2002,2005 National
Institute of General Medical Sciences, ad hoc study section member Genetics,
Biochemistry, MBC2, MGA, MGC Study sections. 2005 National
Cancer Institute Intramural Review Group (Laboratory of Biochemistry) 2006-present National
Institute of General Medical Sciences MGC Study section, permanent member 1998-present Associate
Editor: Genes to Cells 2003-4
American Society for
Microbiology, Chairman Division X (Eukaryotic Microbiology). 2002
Gordon Research Conferences, co-Vice Chair for Conference on Meiosis 2004 Gordon
Research Conferences, co-Chair for Conference on Meiosis 1993-present Peer
reviewer for the following journals: Cancer Research, Cell, Chromasoma, The EMBO Journal, EMBO Reports,
Gene, Genes and Development, Genetics, Journal of Cell Biology, Molecular and
Cell Biology, Nature, Nature Structural and Molecular Biology, The Plant
Cell, Proc. Natl. Acad. Sci., USA, Science, Oncogene, J. Biol. Chem., PLoS Biology, PLoS Genetics, Cancer Research, Genes to Cells,
Journal of Molecular Biology, Journal of Cell Biology. |
PRESENTATIONS
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Only two types of
presentations are listed: External 50-minute invited seminars at academic
institutions and 15-40 minute invited platform presentations at international
meetings (¥). 1993 ¥Genetics Society of
America, Yeast Meeting, Seattle,WA ÒCytological detection of RecA homologues in
meiosisÓ 1994 University of Western
Ontario, Department of Biology, London Ontario, CANADA ÒCytological
detection of meiotic recombinationÓ
¥Gordon
Conference on Meiosis, Plymouth State College, Plymouth, NH ÒDetection
of RecA homologues Rad51 and Dmc1 by immunostainingÓ University
of Wisconsin, Department of Genetics, Madison, WI ÒCytological
detection of recombination complexes.Ó Loyola
Medical School, Department of Molecular Biology, Maywood, IL ÒRecombination
complexes and checkpoint control in meiosis.Ó 1995 Osaka University,
Department of Biology, Toyonaka, JAPAN ÒMeiotic
recombination and reductional chromosome segregationÓ ¥FEBS
Lecture Course: Genetics, Biochemistry and Ultrastructure of Meiosis Obertraun,
AUSTRIA ÒMeiotic
recombination complexes and regulation of meiotic divisionÓ University
of Indiana, Department of Biology, Bloomington, IN ÒMeiotic
recombination complexes and regulation of meiotic divisionÓ 1996 ¥Gordon
Conference on Meiosis, Colby-Sawyer College, New London, New Hampshire ÒRegulation
of recombination partner choiceÓ ¥EMBO
Workshop: Mechanisms and Consequences of Genetic Recombination, Seillac,
FRANCE ÒActivation
of a DMC1-independent pathway
for resolution of Meiotic DSBsÓ ¥FASEB
Summer Research Conference on Yeast Chromosomes, Snowmass, CO ÒRegulation
of meiotic recombinationÓ 1997 Yale University Medical
School, Department of Genetics, New Haven, CT ÒRegulation
of meiotic recombinationÓ University
of Arizona, Department of Biology, Tucson, AZ ÒRegulation
of meiotic recombinationÓ ¥DNA
Replication, Recombination, and Repair Symposium, Nagoya, JAPAN ÒCytological
investigation of meiotic recombinationÓ 1998 ¥Genetics Society of
America Symposium on DNA Repair: Bacteria to Humans, Airlie House,
Warrenton, VA ÒAssembly
of recombination complexes and checkpoint control during meiosis. ¥Gordon
Conference on Meiosis, Colby-Sawyer College, New London, NH ÒAssembly
of recombination complexesÓ ¥FASEB
Summer Research Conference on Yeast Chromosomes, Snowmass, CO ÒAssembly
of recombination complexesÓ ¥University
of Texas, Center for Molecular Medicine, San Antonio, TX ÒAssembly
of meiotic recombination complexesÓ
¥Wayne
State, Center for Molecular Medicine and Genetics,
Detroit, MI ÒAssembly
of meiotic recombination complexesÓ 1999 University of Oregon,
Department of Molecular Biology ÒAssembly
and regulation of meiotic recombination complexesÓ Cornell
University, Department of Genetics, Ithaca, NY ÒAssembly
of recombination complexesÓ ¥FASEB
Summer Research Conference on Recombination and Genome rearrangement, Snowmass,
CO (Session Chair) ÒAssembly
of recombination complexesÓ 2000
Brown University,
Providence, RI ÒAssembly
of homologous recombination complexes
¥Gordon Conference on Meiosis, Colby-Sawyer College, New
London, NH ÒAssembly
of recombination complexesÓ ¥EMBO
Workshop: Mechanisms and Consequences of Genetic Recombination, Seillac,
FRANCE(Session Chair) ÒYeast
Dmc1 promotes strand annealing and D-loop formation in vitroÓ ¥National Academy of Science Colloquium
ÒLinks between recombination and replication: Vital roles of recombinationÓ Irvine, CA. ÒAssembly of RecA-like recombinases:
Distinct roles for mediator proteins in mitosis and meiosis 2001
¥Society for
Experimental Biology Annual Meeting. Canterbury, UNITED KINGDOM ÒStructural features of recombination complexes in S.
cerevisiaeÓ ¥Radiation Research Society Annual Meeting. San
Juan, Puerto Rico ÒRegulation of assembly of recombinational repair
complexesÓ University
of Wisconsin, Department of Genetics, Madison, WI ÒCoordination
of meiotic recombinationÓ Sloan-Kettering Cancer Institute, New York, NY ÒCoordination
of meiotic recombinationÓ 2002 ¥Keystone Symposium on Molecular Mechanisms of
DNA Replication and Recombination, Snowbird, CO ÒThe
Role of Dmc1 and Tid1 in Homologous Strand Invasion and Crossover
InterferenceÓ ¥EMBO
Workshop: Mechanisms and Consequences of Genetic Recombination, Seillac,
FRANCE ÒCoordination of DNA Ends
during Meiotic RecombinationÓ ¥Gordon
Conference on Meiosis (vice Chairman), Colby-Sawyer College, New London, NH ÒCoordination
of DNA Ends during Meiotic RecombinationÓ ¥FASEB Summer Research Conference on Yeast
Chromosomes, Snowmass, CO (Session Chair) ÒRole
of DNA Damage Checkpoint Genes in Regulating Meiotic RecombinationÓ ¥Federation
of Asian Organizations for Biochemistry and Molecular Biology, Annual
Meeting. TAIWAN ÒRole
of Dmc1 and Tid1 in Strand Invasion and Crossover ControlÓ ¥Banbury
Conference on Recombination (Discussion Leader). Cold Spring Harbor, NY. ÒMeiotic
RecombinationÓ 2003 ¥Gordon Conference on
Radiation Oncology, Ventura, CA ÒPeptide
inhibition of XRCC3Ó ¥FASEB Summer Research Conference on Recombination
and Genome Rearrangement, Snowmass,
CO ÒGenetic
Analysis of BRCA1 function in DT40 CellsÓ ¥EMBO
Workshop: Meiosis, Obertraun, AUSTRIA
ÒSpecialized functions of Rad51 and Dmc1Ó 2004
¥EMBO Workshop: Mechanisms and
Consequences of Genetic Recombination, Seillac,
FRANCE ÒTid1
promotes dissociation of Dmc1 from non-specific sites on chromatinÓ ¥Gordon Conference on Meiosis, Colby-Sawyer
College, New London, NH (Meeting
Co-Chairman) ÒIntroductory OverviewÓ 2005 Institute of Biological
Chemistry, Academica Sinica Nankang, TAIWAN ÒRegulation of
Recombinase Assembly during DNA repair and meiosisÓ Hsin
Chu Univeristy Hsin Chu, TAIWAN ÒRegulation of
Recombinase Assembly during DNA repair and meiosisÓ ¥FASEB Summer Research Conference on Recombination
and Genome rearrangement, Snowmass,
CO ÒSuppression
of BRCA1 mutants by overexpression of RAD51Ó University
of Iowa, Department of Genetics, Iowa City, IowaÓ ÒRegulation of Recombinase Assembly during DNA repair and
meiosisÓ ¥American
Society for Microbiology Annual Meeting, Atlanta GA (Session Chair) ÒTid1
promotes dissociation of Dmc1 from non-specific sites on chromatinÓ ¥EMBO
Workshop: Meiosis, El Escorial, SPAIN (Session Chair) ÒTid1 promotes dissociation of Dmc1 from
non-specific sites on chromatinÓ Department of Radiation Oncology Washington U. Med.
School, St. Louis, MO. ÒRecombinase Dynamics in Breast Cancer and MeiosisÓ 2006 U. of California, Davis, CA ÒDynamics of Meiotic RecombinaseÓ ¥Gordon Conference on Meiosis, Colby-Sawyer
College, New London, NH
ÒEvidence for Synthesis-Dependent Strand AnnealingÓ 2007 U. of Indiana, Bloomington Indiana.
ÒRecombinase Dynamics in Cancer and MeiosisÓ |