Disclaimer:  The following information is drawn from materials prepared by candidates for promotion to associate professor in one of the scholarship-requiring tracks (RS and CS).  It is intended to illustrate activities and materials that might support promotion.  In using these materials, please note the following:             *The Provost (and, in some cases, the President) are the University officers authorized to approve promotions.  All levels of review below these officers are advisory.             *Only Departments are empowered to propose promotions, and the Divisional Dean is charged with transmitting such proposals to the Provost or returning them to the Department.             *The judgment of the Department, Dean, and Provost will therefore be critical to assessing qualification for promotion.             *Materials considered by the Department, Dean, and Provost will also (and always) include confidential evaluations obtained from outside the University.  Materials considered by the Provost will include the confidential evaluations of the Dean and Department, and those considered by the Dean will include the confidential evaluations of the Department.             *Thus, the following materials are ONLY PART of a complete proposal for promotion, whereas promotion is based on the ENTIRE proposal.   Therefore, it should not be assumed that a record comparable to that below will necessarily result in promotion, or that a record not comparable to that below will fail to result in promotion.  The Departmental Chair is likely to be the best source of advice as to whether promotion is feasible and, when it is not, what additional activity may result in qualification for promotion.             *This document has been prepared as a tool for use by assistant professors in the Division of the Biological Sciences.  Other individuals who may find it informative are Department Chairmen, Section Heads, Committee Chairmen, senior faculty and potential recruits.  Its intent is to help guide individuals and their departments as they think about promotion to Professor.  This document is not intended to list the elements that every promotion proposal will be expected to address.  The following information is presented for information purposes only and is not intended to create any contract or agreement, and its contents are subject to addition, deletion, and change without prior notice.
Name:		Eric Svensson, M.D., Ph.D.

Department of Primary Appointment:

Medicine

Secondary appointments:

Committee on Developmental Biology Committee on Molecular Pathogenesis and Molecular Medicine

DEPARTMENT: What is the candidate's field or specialization?*

heart development

LAY SUMMARY:

Dr. Svensson is a physician scientist. His research interest is in understanding the genes involved in forming the heart. He has focused on one gene called FOG-2, a transcription factor that functions to shut off a host of other genes during heart development. Dr. Svensson has defined the domain of this protein responsible for this repression and found that similar domains exist in other transcriptional repressors. He has also defined a mechanism by which this domain functions biochemically. Finally, he has demonstrated that FOG proteins are important for fish heart development, suggesting that the function of this family of transcription factors is evolutionally conserved. In addition to his research, Dr. Svensson is a practicing cardiologist, seeing patients in the inpatient and outpatient setting. Dr. Svensson teaches medical housestaff during his months on service, as well as teaching and mentoring graduate students within his laboratory. He also co-directs the physician-scientist training program, a program that identifies, recruits, and supports M.D./Ph.D. students or medical students with significant research experience for combined clinical and research training as residents and fellows.

CURRICULUM VITAE

Editorial and Review Experience

Journals

2002-Present Ad Hoc Reviewer for Molecular and Cellular Biology

2005 Ad Hoc Reviewer for Journal of Structural Biology

2005 Ad Hoc Reviewer for Microvascular Research

2005-Present Ad Hoc Reviewer for Development

2006-Present Ad Hoc Reviewer for Developmental Biology

2006-Present Ad Hoc Reviewer for Circulation Research

Peer Review Panels

2003 Member, NHLBI study section for Pediatric Heart Development

and Disease SCCOR

2004-Present Member, American Heart Association National Study Section on Basic Cell and Molecular Biology

2006-2007 Member, NIH Special Emphasis Study Section

Membership in Professional Societies

2001-Present Member, Council on Basic Cardiovascular Sciences,

American Heart Association

2006-Present Member, Central Society for Clinical Research

Organizing Roles in Scientific Meetings

2007-Present Chairman, Local Organizing Committee,

2012 Weinstein Cardiovascular Development Meeting

PRESENTATIONS

Invited Presentations

December 2002 “The Role of the Transcriptional Co-repressor FOG-2 in Cardiac Development” Etiology and Morphogenesis of Congenital Cardiovascular Disease in the Pos-Genomic Era, Tokyo, Japan.

April 2004 “The Role of FOG-2 in Coronary Development” 2004 Coronary Vasculogenesis Meeting, Estes Park, CO.

April 2005 “FOG genes are Required for Cardiac Looping in Zebrafish” Keystone Symposium on Cardiac Diseases and Regeneration, Steamboat Springs, CO.

January2006 “FOG Proteins in Cardiac Development”, Department of Physiology, University of Illinois at Chicago.

October 2006 “Career Advice for a Physician-Scientist”, Medical Scientist Training Program, Indiana University

January2007 “FOG Proteins in Cardiac Development”, Cardiology Grand Rounds, University of North Carolina

April 2007 “The role of FOG-2 in Mediating Chromatin Remodeling during Cardiac Development” Medical Scientist Training Program, University of Illinois at Chicago

Recent Abstracts Presented at National Scientific Meetings

1. Najib, K., Bruce, A., Walton, Z., Dale, R.M., Ho, R., and Svensson, E.C. “The Role of FOG Genes in Zebrafish Cardiac Development” 2004 Keystone Symposia on Cardiac Development, Keystone, CO.

2. Votroubek, A.E., Lin, A., Wilk, J. and Svensson, E.C. “The N-Terminus of FOG-2 defines a Novel Transcriptional Repression Domain” 2004 Keystone Symposia on Cardiac Development, Keystone, CO.

3. Walton, Z., Bruce, A., Najib, K., Ahn, D., Ho, R., and Svensson, E.C. “FOG Genes are Required for Cardiac Development in Zebrafish” 2004 6^th International Meeting on Zebrafish Development & Genetics, Madison, WI.

4. Flagg, A. E., Early, J., and Svensson, E.C. “FOG-2 Regulates Endothelial to Mesenchymal Transformation in Developing Heart Valves” 2005 American Heart Association Meeting, Dallas, TX.

5. Kim, G. H., and Svensson, E.C. “FOG-2 Expression is Regulated by microRNAs” 2005 Keystone Symposium on Molecular Biology of Cardiac Diseases and Regeneration, Steamboat Springs, CO.

6. Dale, R.M., Remo, B.F., and Svensson, E.C. (2005) “An Alternative Promoter within the FOG-2 Gene Generates an Isoform of FOG-2 Lacking the FOG Repression Motif” 2005 Weinstein Conference on Cardiovascular Development, Tucson, AZ.

7. Samant, S. A., Roche, A. E., and Svensson, E. C. (2006) “The N-Terminus of FOG-2 interacts with MTA-1 and 2 to mediate Transcriptional Repression” 2006 Keystone Symposium on Molecular Biology of Cardiac Diseases and Regeneration, Santa Fe, NM.

8. Gao, Z., Flagg, A. E., Earley, J. U., and Svensson, E. C. (2007) “Ets-1 Deficient Mice Die Perinatally due to a Membranous Ventricular Septal Defect” 2007 Weinstein Conference on Cardiovascular Development, Indianapolis, IN.

9. Flagg, A. E., Olivey, H. E., and Svensson, E. C. (2007) “PDGF-BB Rescues Coronary Vessel Formation in FOG-2 Deficient Hearts” 2007 Weinstein Conference on Cardiovascular Development, Indianapolis, IN.

10. Roche, A. E., Bassett, B., Samant, S. A., and Svensson, E. C. (2007) “The N-terminus of FOG-2 Interacts with the MTA Proteins of the NuRD Complex to Mediate Transcriptional Repression” 2007 Weinstein Conference on Cardiovascular Development, Indianapolis, IN.