Disclaimer:  The following information is drawn from materials prepared by candidates for promotion to associate professor in one of the scholarship-requiring tracks (RS and CS).  It is intended to illustrate activities and materials that might support promotion.  In using these materials, please note the following:

               *The Provost (and, in some cases, the President) are the University officers authorized to approve promotions.  All levels of review below these officers are advisory.

               *Only Departments are empowered to propose promotions, and the Divisional Dean is charged with transmitting such proposals to the Provost or returning them to the Department.

               *The judgment of the Department, Dean, and Provost will therefore be critical to assessing qualification for promotion.

               *Materials considered by the Department, Dean, and Provost will also (and always) include confidential evaluations obtained from outside the University.  Materials considered by the Provost will include the confidential evaluations of the Dean and Department, and those considered by the Dean will include the confidential evaluations of the Department.

               *Thus, the following materials are ONLY PART of a complete proposal for promotion, whereas promotion is based on the ENTIRE proposal.   Therefore, it should not be assumed that a record comparable to that below will necessarily result in promotion, or that a record not comparable to that below will fail to result in promotion.  The Departmental Chair is likely to be the best source of advice as to whether promotion is feasible and, when it is not, what additional activity may result in qualification for promotion.

               *This document has been prepared as a tool for use by assistant professors in the Division of the Biological Sciences.  Other individuals who may find it informative are Department Chairmen, Section Heads, Committee Chairmen, senior faculty and potential recruits.  Its intent is to help guide individuals and their departments as they think about promotion to Professor.  This document is not intended to list the elements that every promotion proposal will be expected to address.  The following information is presented for information purposes only and is not intended to create any contract or agreement, and its contents are subject to addition, deletion, and change without prior notice.

Name

Bana Jabri, MD, PhD

 

Department of Primary Appointment:

Department of Pathology

 

Secondary appointments:

Department of Medicine

 

Proposed rank:

ASSOCIATE PROFESSOR

 

Proposed track:

RESEARCH SCHOLAR (TENURE)

DEPARTMENT: What is the candidate's field or specialization?*

Physician-Scientists who study mucosal immunology in the context of human diseases, especially of the gastrointestinal tract.

LAY SUMMARY:

Celiac disease is a complex intestinal inflammatory disorder that appeared with agriculture and the introduction of wheat in the history of mankind. The disease is caused in genetically predisposed individuals by a reaction to gluten, a wheat protein that is particularly difficult to digest. Gluten initiates an immunological response causing the complete destruction of the cells lining the gut, Our studies focused on the immune cells (lymphocytes) found in contact with intestinal cells and elucidated the molecular mechanisms by which lymphocytes destroy intestinal cells. We found that exposure of intestinal cells to gluten activated a stress pathway that aberrantly exacerbated the expansion of intestinal lymphocytes and their ability to kill intestinal cells. We identified the biochemical components of this pathway from the cell surface receptors mediating cellular interactions to the molecules propagating the signals inside the cells. A similar pathway appears to be involved in other immunological diseases such as type I diabetes and rheumatoid arthritis.

Our studies have identified a new level of crosstalk between stressed tissues and the immune system which governs immune surveillance. We suggest that the biochemical components of this crosstalk may be the target of new therapeutic strategies aimed at controlling immune-mediated diseases such as celiac disease, type I diabetes and rheumatoid arthritis. In addition to my research I am an active participant in teaching immunology to undergraduates, graduate students and post-doctoral fellows. My administrative duties are within the BSCD, graduate program in pathology and Committee of Immunology.

 

CURRICULUM VITAE

Awards and Honors

1991                   Prize of Excellence in Pediatric Gastroenterology

1989-1990       Fellowship of the ÒFondation pour la Recherche MedicaleÓ

1991-1992       INSERM fellowship for post Doctoral studies

1992-1994       Fogarty Visiting Fellowship (NIH)

Membership

               American Gastroenterology Association

               American Immunology Association

 

 

ADVISORY FUNCTIONS

 

Study Sections

               1994-1998       INSERM Gastroenterology/Nutrition study section

1995-1999           INSERM Pediatric study section

2000                   Ad-Hoc reviewer for the Celiac Program Project (NIH)

2000-2002       Ad-Hoc reviewer for the CrohnÕs and Colitis foundation

2005                   NIH/NIAID Special Emphasis Panel on "HLA Region Genetics In Immune-Mediated Diseases"

 

Foundations                 

2003-present   Advisory Board for The University of Chicago Celiac Disease Program

2004-   Medical Advisory Board of the National Foundation For Celiac Disease Awareness

Ad-Hoc Reviewer

Immunity, Journal of Clinical Investigation, Blood, Gastroenterology, European Journal of Immunology, PloS

 

ORGANIZATION OF SCIENTIFIC MEETINGS

 

AGA DDW Abstract review (2000-present)

International Congress of Mucosal Immunity Abstract review (2002)

12th International Congress of Mucosal Immunity Steering Committee (2004)

Co-organizer of 12th International Coeliac Symposium (2006)

 

PRESENTATIONS

 

Invited Plenary Talk

-         Conference on Mucosal Immunity. Bruxelles, Belgium, 1993

-         Workshop on Intestinal Inflammatory disease (GETAID). Paris, France, 1996

-         Workshop on classifications of food allergies. Washington DC, USA, 1999

-         Workshop on Intestinal Immunity. Pontoise, France, 2000

-         Third International Workshop on Autoimmunity and Lymphoma. Baltimore,  MD, USA, 2001    

-         Tenth International Symposium on Coeliac Disease.  Paris, France, 2002

-         Seventh annual Meeting of Society for Natural Immunity, San Juan, Puerto Rico, 2002

-         Autoimmune diseases of the digestive tract (organized by the Spanish Society of Immunology), Cordoba, Spain, 2004.

-         Keystone Symposium on Innate Immunity to Pathogens, Colorado, USA, 2005

-         Spanish meeting of Immunology. Cordoba, Spain, 2005

-         Workshop on ÔGenetic control of T cell activationÕ, Lofoten, Norway, 2005

-         Dageraad  Symposium : ÒMHC class I (like) molecules: Effects and Defects ", Leiden, Netherlands, 2005

-         9th Meeting of the Society for Natural Immunity. Hawaii. 2005

-         Keystone Symposium on Innate Immune recognition, 2006

 

Chair

- Tenth International Symposium on Coeliac Disease.  Paris, France, 2002

- AGA DDW, State of the Art lecture on the pathogenesis of celiac Disease.   Orlando, FL, USA, 2003

- International mucosal Immunity meeting, Boston, USA, 2005

 

Oral Presentations of Abstract

- Keystone Symposium, Mucosal Immunity, USA, 1999

- Keystone Symposium, Interface between Innate and Adaptive Immunity, USA, 2001

- Keystone Symposium, Lymphocyte Activation, USA, 2002

- 7th Annual Meeting of the society for Natural Immunity, Puerto Rico, USA, 2002 (plenary talk)

 - AGA, DDW, San Francisco, USA, 2002

- AGA, DDW, New Orleans, USA, 2004

- Eleventh International Symposium on Coeliac Disease, Belfast, Ireland, 2004 (plenary talks)

 

Extramural Seminar Speaker

- Institut Pasteur, Paris, 1999

- H™pital Necker-Enfants-Malades, Paris, 2000

- Columbia University, NY, 2000

- Johns Hopkins, Baltimore, 2001

- Harvard University, Boston, 2002

- Columbia University, NY, 2003

- Mayo Clinic, Rochester, 2003

- Columbia University, NY, 2004

- Institut de Pharmacologie MolŽculaire et Cellulaire, Nice, 2004

- Celiac Disease Foundation, Stanford, 2004

- Scripps, San Diego, 2005

- University of Oslo, Oslo, 2005

- Institut Curie, Paris, 2005