Name	Nicholas Hatsopoulos, Ph.D.

Department of Primary Appointment:

Organismal Biology and Anatomy

Secondary appointments:

Committee on Computational Neuroscience Committee on Neurobiology Dept. of Neurology

DEPARTMENT: What is the candidate's field or specialization?

Behavioral neurophysiology of neocortical activity involved in movement control

LAY SUMMARY:

Dr. Hatsopoulos has already made major discoveries that challenge the traditional view of how the forebrain controls movements. Three of the most important discoveries are

(1) Dr. Hatsopoulos showed that neurons in the motor cortex (the part of the forebrain controlling movements) encode trajectories of motion, a concept which is fundamentally different than the long-standing, prevailing view that motor cortex neurons encode time-independent parameters of movements.

(2) Dr. Hatsopoulos discovered that oscillations in the patterns of activity within the motor cortex show remarkable, coherent organization, propagating as waves across the surface of the motor cortex, and that these waves encode information related to the goal (target) of the movement.

(3) Dr. Hatsopoulos showed that the motor cortex oscillations can be separated into different frequency bands, which predict the direction of the target of the movement.

Dr. Hatsopoulos plays an important role in the Department’s teaching mission by teaching Cognitive Neuroscience, a critical course in the Committee on Computational Neuroscience and Integrative Neuroscience (Psychology) sequences for graduate students.

CURRICULUM VITAE

JOURNAL & GRANT REVIEWS

Experiment Brain Research

Journal of Neural Engineering

Journal of Neurophysiology

Journal of Neuroscience

Nature

Nature Neuroscience

Neural Computation

Israeli Government External Grant Reviewer

NIH-NINDS External Reviewer for RFP on Biomaterials for the CNS

NIH-NINDS Bioengineering Research Partnership (BRP) study section reviewer

NIH-NINDS SMI ad hoc study section reviewer

Neural Information Processing Systems (NIPS) conference proceedings reviewer

MEETING ORGANIZATION

1998 Organized with Harel Shouval a workshop on temporal coding as part of the Neural Information Processing Systems (NIPS) conference, Breckenridge, CO.

2004 Organized the 4^th Annual Neural Coding Workshop, University of Chicago, Chicago, IL.

2005 Co-organized a Brain-Machine workshop at the Computational and Systems

Neuroscience 2005 conference in Snowbird, UT.

2006 Co-organized the AREADNE (Research in Encoding & Decoding of Neuronal

Ensembles) conference on Santorini, Greece.

2008 Co-organizing the AREADNE (Research in Encoding & Decoding of Neuronal

Ensembles) conference to be held on Santorini, Greece.

PRESENTATIONS

Invited Talks

Hatsopoulos, N.G. (1995). Computation of collision avoidance in a visual interneuron. Invited talk at the Dept. of Neuroscience, University of California at Berkeley, Berkeley, CA.

Hatsopoulos, N.G. (1996). Computation of collision avoidance in a visual interneuron. Invited talk at the Dept. of Psychology, University of Connecticut at Storrs, Storrs, CT.

Hatsopoulos, N.G. (1997). Coupling neural and mechanical dynamics in motor control.

Invited talk to be given at the Neuromuscular Research Center, Boston University, Boston, MA.

Hatsopoulos, N.G. (1999). Ensemble coding of movement in motor cortex. Invited talk given at the Dept. of Psychology, University of St. Andrews, St. Andrews, Scotland.

Hatsopoulos, N.G. (2000). Ensemble coding of movement in motor cortex. Invited talk given at the Health Sciences & Technology Program, MIT, Cambridge, MA.

Hatsopoulos, N.G. (2000). Decoding ensembles of motor cortical neurons. Invited talk sponsored by the Center for Neuromorphic Systems Engineering, Caltech, Pasadena, CA.

Hatsopoulos, N.G. (2001). Towards the development of a neuro-motor prosthetic device. Invited talk given at the First Annual Workshop on Neural Coding, Chicago, IL.

Hatsopoulos, N.G. (2002). Ensemble coding in motor cortex. Invited talk at Queens University, Kingston, Ontario, Canada.

Hatsopoulos, N.G. (2002). Ensemble coding in motor cortex. Invited talk at University of Kansas, Kansas City, KS.

Hatsopoulos, N.G. (2002). Ensemble vs. Population Codes in cortex. Invited talk sponsored by the Dept. of Physiology, Northwestern University, Chicago, IL.

Hatsopoulos, N.G. (2002). Ensemble vs. Population Codes in cortex. Bodian Lecture at the Johns Hopkins University, Baltimore, MD.

Hatsopoulos, N.G. (2002). Cortical control of a Neuro-motor Prosthesis. Invited talk at the University of Maryland Bioscience Research and Technology Review Day, College Park, MD.

Hatsopoulos, N.G. (2003). Decoding movement using motor and premotor cortical ensembles. Invited talk at Loyola University, Chicago, IL.

Hatsopoulos, N.G. (2003). Decoding movement using motor and premotor cortical ensembles. Invited talk at Stanford University, Palo Alto, CA.

Hatsopoulos, N.G. (2003). Multi-electrode recording in motor cortex. Developments in neural probe technologies and applications symposium at the 33^rd Annual Meeting of the Society for Neuroscience, New Orleans, LA.

Hatsopoulos, N.G. (2004). Current challenges in the development of a Brain-Computer Interface. Invited talk at the Chicago Chapter of the Association for Computing Machinery, Chicago, IL.

Hatsopoulos, N.G. (2004). The language of action in the motor cortex. Invited talk at the University of Minnesota, Minneapolis, MN

Hatsopoulos, N.G. (2005). Coding of action from cortical ensembles. Invited talk at Texas A&M University, College Station, TX.

Hatsopoulos, N.G. (2005). A language of action in the motor cortex. Invited talk at the California Institute of Technology, Pasadena, CA.

Hatsopoulos, N.G. (2005). Computing using large neuronal ensembles. Invited talk at the Dean’s Distinguished Lecture Series, BSD, University of Chicago, Chicago, IL.

Hatsopoulos, N.G. (2005). The language of action in the motor cortex. Invited talk at the University College London, London, England.

Hatsopoulos, N.G. (2005). Cortically controlled brain machine interface. Invited talk at the Statistics of Networks Workshop at the National Academy of Sciences, Washington, DC.

Hatsopoulos, N.G. (2005). A language of action in the motor cortex. Invited talk at Mt. Sinai School of Medicine, New York, NY.

Hatsopoulos, N.G. (2005). A language of action in the motor cortex. Invited talk at Washington University, St. Louis, MO.

Hatsopoulos, N.G. (2005). The language of action in the motor cortex. Invited talk at the University of Texas, San Antonio, TX.

Hatsopoulos, N. G. (2006). Mind over matter: Developments in brain-machine interfaces. Invited talk at the Saturday Seminars in Biology Series at the University of Chicago.

Hatsopoulos, N.G. (2006). Brain-machine Interface: From basic science to the patient. Invited keynote address for Practice, Research, & Trends for Management of Patients with Spinal Cord Injuries: An Interdisciplinary Approach at the Rehabilitation Institute of

Chicago.

Hatsopoulos, N.G. (2006). Does Size Matter? Invited talk at the State of the Science Workshop: Functional Restoration for the Stroke Survivor: Informing the Efforts of Engineering, La Jolla, CA.

Hatsopoulos, N.G. (2006) Listening to the neuronal ensemble: Turning thought into action. Invited talk at The New Architecture of Science and Medicine Event, Chicago, IL.

Hatsopoulos, N.G. (2006). Current developments in a cortically controlled brain machine Interface. Invited talk at Interface 2006, 38^th Symposium on the interface of statistics, cmputing science, and applications, Pasadena, CA.

Hatsopoulos, N.G. (2006) Developments in brain-machine interface technology: Turning Thought into Action. Invited talk at the Fermilab Colloquium, Fermilab, Batavia, IL.

Hatsopoulos, N.G. (2006). Large-scale patterns of spiking activity and local field potentials in the motor cortex. Invited talk at the 14^th annual Dynamical Neuroscience Satellite Symposium: Frontiers in Neural Signal Processing, Atlanta, GA.

Hatsopoulos, N.G. (2007) Encoding of movement fragments in motor cortical ensembles. Invited talk at the Being on Time Conference, Hebrew University of Jerusalem, Jerusalem, Israel.

Hatsopoulos, N.G. (2007) Brain-machine interface technology: From basic science to the patient. Invited talk at the Chicago Women’s Board, Chicago, IL

Hatsopoulos, N.G. (2007) Propagating waves in motor cortex. Invited talk at the Physiology Dept. Seminar Series, Northwestern University, Chicago, IL

Hatsopoulos, N.G. (2007) Neuromotor brain-machine interfaces: Turning thought into action. Invited talk at the 3^rd International Symposium of Biomedical Engineering, Technologico de Monterrey, Monterrey, Mexico.

Hatsopoulos, N.G. (2007) Neuro-replacement- Mind activated robotics. Invited talk at American Society for Artificial Internal Organs conference, Chicago, IL.

Oral presentations

Hatsopoulos, N.G., and Warren, W.H., Jr. (1990). Visual navigation with a neural network. Paper presented at the 1990 International Joint Conference on Neural Networks, Washington, DC.

Hatsopoulos, N.G. (1992). A neural pattern generator that tunes into the physical dynamics of the limb system. Paper presented at the 1992 International Joint Conference on Neural Networks, Baltimore, MD.

Hatsopoulos, N.G., and Anderson, J.A. (1992). Collision-avoidance system based on optical flow. Paper presented at Intelligent Vehicles ‘92, Detroit, MI.

Hatsopoulos, N.G., Gabbiani, F., and Laurent, G. (1995). Elementary computation of collision in a visual interneuron. Paper presented at the 25th annual meeting of the Society for Neuroscience, San Diego, CA.

Hatsopoulos, N.G., Ojakangas, C.L., Donoghue, J.P. (1996). Temporal coherence patterns between simultaneously recorded motor cortical neurons during planar reaching movements. Paper presented at the 26th annual meeting of the Society for Neuroscience, Washington, DC.

Hatsopoulos, N.G., Sanes, J.N., Donoghue, J.P. (1996). Dynamic correlations in unit firing of motor cortical neurons related to movement preparation and action. Paper presented at the Computation Neuroscience ‘96 meeting, Boston, MA.

Hatsopoulos, N.G., Ojakangas, C.L., Donoghue, J.P. (1997). Planning of sequential arm movements from simultaneously recorded motor cortical neurons. Paper presented at the 27th annual meeting of the Society for Neuroscience, New Orleans, LA.

Hatsopoulos, N.G., Paninski, L., Donoghue, J.P. (1998). Combining movement

segments into a unified sequential action. Paper presented at the 28th annual

meeting of the Society for Neuroscience, Los Angeles, CA.

Hatsopoulos, N. G., Geman, S., Amarasingham, A. & Elie Bienenstock, E. (2002). At what time scale does the nervous system operate? Paper presented at the CNS2002, Conference, Chicago, IL.

Hatsopoulos, N. G., O’Leary. J., and Joshi, J. (2003). Current challenges in the development of a cortical brain-machine interface. Proceedings of the 25^th Annual Conference of the IEEE Engineering in Medicine and Biology Society, Cancun, Mexico, Sept. 17-Sept. 21.

Hatsopoulos, N. G., Joshi, J. (2003). Multi-electrode recording from motor cortex in behaving primates. Proceedings of the 25^th Annual Conference of the IEEE Engineering in Medicine and Biology Society, Cancun, Mexico, Sept. 17-Sept. 21.

Hatsopoulos, N. G. Current state and future directions in brain-machine interfaces (2005). Talk presented at the COSYNE workshop on Emerging Directions in Cortical Brain-Machine Interfaces for Control, Snowbird, UT.